Drug search by name

Pyrazinamide and Hepatotoxicity

Result of checking the interaction of drug Pyrazinamide and disease Hepatotoxicity for safety when used together.

Check result:

Pyrazinamide <> Hepatotoxicity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of pyrazinamide is contraindicated in patients with severe liver damage. Pyrazinamide may cause hepatocellular injury, particularly in patients with underlying liver disease and during coadministration with other hepatotoxic agents including other antituberculous drugs such as isoniazid and rifampin. Therapy with pyrazinamide should be administered cautiously and under strict medical supervision in patients with liver disease or a history of alcoholism. Serum transaminases (ALT, AST) and bilirubin should be measured at baseline and monitored closely during therapy. Patients should be instructed to discontinue the drug promptly and seek medical attention if signs and symptoms of hepatic injury develop, including fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice. To lessen the risk of hepatotoxicity, the maximum dosage should not exceed 2 g/day when treatment is administered daily or 3 g/day when administered twice weekly.

References:

Mandell GL, Bennett JE, Dolin R, eds.. "Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases. 4th ed." New York, NY: Churchill Livingston 1 (1995):
Cohen CD, Sayed AR, Kirsch RE "Hepatic complications of antituberculosis therapy revisited." S Afr Med J 63 (1983): 960-3
CDC. Centers for Disease Control. "Update: fatal and severe liver injuries associated with rifampin and pyrazinamide for latent tuberculosis infection, and revisions in American Thoracic Society/CDC recommendations--United States, 2001." Morb Mortal Wkly Rep 50 (2001): 733-5
"Product Information. Pyrazinamide (pyrazinamide)." VersaPharm Inc, Marietta, GA.
Danan G, Pessayre D, Larrey D, Benhamou JP "Pyrazinamide fulminant hepatitis: an old hepatotoxin strikes again." Lancet 2 (1981): 1056-7

Pyrazinamide

Generic Name: pyrazinamide

Brand Name:

Synonyms: n.a.

What is Pyrazinamide?