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Procainamide capsules and Renal dysfunction

Result of checking the interaction of drug Procainamide capsules and disease Renal dysfunction for safety when used together.

Check result:

Procainamide capsules <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Procainamide is primarily eliminated by the kidney. The serum concentration of procainamide is increased and the half-life prolonged in patients with renal impairment. Therapy with procainamide should be administered cautiously in patients with renal dysfunction and dosage modifications should be made based on the degree of renal impairment.

References:

"Product Information. Procan SR (procainamide)." Parke-Davis, Morris Plains, NJ.
Gibson TP, Atkinson AJ, Matusik E, et al "Kinetics of procainamide and N-acetylprocainamide in renal failure." Kidney Int 12 (1977): 422-9
Stec GP, Atkinson AJ, Nevin MJ, et al "N-acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis." Clin Pharmacol Ther 26 (1979): 618-28
Gibson TP, Matusik EJ, Briggs WA "N-acetylprocainamide levels in patients with end-stage renal failure." Clin Pharmacol Ther 19 (1975): 206-12
"Product Information. Pronestyl (procainamide)." Apothecon Inc, Plainsboro, NJ.
Galeazzi RL, Sheiner LB, Lockwood T, Benet LZ "The renal elimination of procainamide." Clin Pharmacol Ther 19 (1975): 55-62

Procainamide capsules

Generic Name: procainamide

Brand Name: Pronestyl, Procan SR, Pronestyl-SR, Procanbid

Synonyms: Procainamide (injection), Procainamide

What is Procainamide capsules?