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Procainamide and Systemic lupus erythematosus

Result of checking the interaction of drug Procainamide and disease Systemic lupus erythematosus for safety when used together.

Check result:

Procainamide <> Systemic lupus erythematosus

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of procainamide is contraindicated in patients with established systemic lupus erythematosus (SLE), since aggravation of the symptoms is highly likely. A positive antinuclear antibody test (+ANA), with or without symptoms of SLE, often results from chronic therapy with procainamide in patients without SLE. An SLE-like syndrome, rarely involving pathologic renal changes, can occur following prolonged procainamide therapy. The benefit versus risk should be evaluated in the presence of a +ANA in a patient without a history of or predisposition to SLE.

References:

Amadio P, Cummings D, Dashow L "Procainamide, quinidine, and lupus erythematosus." Ann Intern Med 102 (1985): 419-20
McDonald E, Marino C "Procainamide-induced lupus in the elderly." Hosp Pract (Off Ed) 28 (1993): 95-8
"Product Information. Pronestyl (procainamide)." Apothecon Inc, Plainsboro, NJ.
"Product Information. Procan SR (procainamide)." Parke-Davis, Morris Plains, NJ.
Zech P, Colon S, Labeeuw M, et al "Nephrotic syndrome in procainamide induced lupus nephritis." Clin Nephrol 11 (1979): 218-21
Heyman MR, Flores RH, Edelman BB, Carliner NH "Procainamide-induced lupus anticoagulant." South Med J 81 (1988): 934-6
Rubin RL, Nusinow SR, Johnson AD, et al "Serologic changes during induction of lupus-like disease by procainamide." Am J Med 80 (1986): 999-1002
Li G, Greenberg C, Currie M "Procainamide-induced lupus anticoagulants and thrombosis." South Med J 81 (1988): 262-4

Procainamide

Generic Name: procainamide

Brand Name: Pronestyl, Procan SR, Pronestyl-SR, Procanbid

Synonyms: Procainamide (injection)

What is Procainamide?