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Probenecid and colchicine and Dehydration

Result of checking the interaction of drug Probenecid and colchicine and disease Dehydration for safety when used together.

Check result:

Probenecid and colchicine <> Dehydration

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Probenecid may promote lithiasis by increasing uric acid concentration in the renal tubules. Adequate hydration is necessary during therapy. Patients who are dehydrated (e.g., due to severe diarrhea or vomiting) may be at increased risk for the development of uric acid kidney stones and should be encouraged to consume additional amounts of liquid or given intravenous fluid. In general, fluid intake sufficient to yield a daily urinary output of at least 2 liters is recommended. Maintenance of a slightly alkaline or neutral urine is also desirable.

References:

"Product Information. Benemid (probenecid)." Merck & Co, Inc, West Point, PA.
Gutman AB "Uricosuric drugs with special reference to probenecid and sulfinpyrazone." Adv Pharmacol 4 (1966): 91-142

Probenecid and colchicine

Generic Name: colchicine / probenecid

Brand Name:

Synonyms: Probenecid and colchicine (Oral)

What is Probenecid and colchicine?