Drug search by name

Pentostatin Intravenous and Renal dysfunction

Generic Name: pentostatin
Dosage Forms: n.a.
Other Brand Names: Nipent

Result of checking the interaction of drug Pentostatin Intravenous and disease Renal dysfunction for safety when used together.

Check result:

Pentostatin Intravenous <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Pentostatin is primarily eliminated by the kidney and is a nephrotoxic drug. Approximately 90% of pentostatin is excreted as unchanged drug and/or metabolites in the urine. Pentostatin clearance is reduced and half-life is increased considerably in patients with moderate renal impairment. Patients with impaired renal function should be treated only when the potential benefit justifies the potential risk. Therapy should be administered cautiously and close clinical monitoring of renal function is recommended prior to initiating therapy and before each dose.

References: