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Pentosan polysulfate sodium and Hepatic impairment

Result of checking the interaction of drug Pentosan polysulfate sodium and disease Hepatic impairment for safety when used together.

Check result:

Pentosan polysulfate sodium <> Hepatic impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of pentosan polysulfate sodium has not been studied in patients with hepatic insufficiency. Because there is evidence of hepatic contribution to the elimination of this drug, hepatic impairment may have an impact on its pharmacokinetics. Caution should be exercised when using pentosan polysulfate sodium in this patient population.

References:

"Product Information. Elmiron (pentosan polysulfate sodium)." Baker Norton Pharmaceuticals, Miami, FL.
MacGregor IR, Dawes J, Paton L, Pepper DS, Prowse CV, Smith M "Metabolism of sodium pentosan polysulphate in man--catabolism of iodinated derivatives." Thromb Haemost 51 (1984): 321-5
Peters M, Witvrouw M, De Clercq E, Ruf B "Pharmacokinetics of intravenous pentosan polysulphate (HOE/BAY 946) in HIV-positive patients." AIDS 5 (1991): 1534-5

Pentosan polysulfate sodium

Generic Name: pentosan polysulfate sodium

Brand Name: Elmiron

Synonyms: Pentosan Polysulfate Sodium

What is Pentosan polysulfate sodium?