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Paclitaxel protein-bound Intravenous and Hepatic dysfunction

Result of checking the interaction of drug Paclitaxel protein-bound Intravenous and disease Hepatic dysfunction for safety when used together.

Check result:
Paclitaxel protein-bound Intravenous <> Hepatic dysfunction
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Paclitaxel is extensively metabolized by the liver. Patients with moderate to severe hepatic impairment may be at increased risk for hepatotoxicity. Additionally, myelotoxicity of paclitaxel may be exacerbated in patients with serum total bilirubin >2 times ULN. Therapy with paclitaxel should be administered cautiously and at a reduced dosage in patients with compromised hepatic function.

References:
  • "Product Information. Taxol (paclitaxel)." Bristol-Myers Squibb, Princeton, NJ.
Paclitaxel protein-bound Intravenous

Generic Name: paclitaxel protein-bound

Brand Name: Abraxane

Synonyms: Paclitaxel protein-bound, PACLitaxel (Protein Bound)

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