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Orthoclone OKT 3 and Neuro/psychiatric dysfunction

Result of checking the interaction of drug Orthoclone OKT 3 and disease Neuro/psychiatric dysfunction for safety when used together.

Check result:

Orthoclone OKT 3 <> Neuro/psychiatric dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of muromonab-CD3 is contraindicated in patients with or predisposed to seizures. Seizures, cerebral edema, confusion, auditory/visual hallucinations, mental status changes, psychosis, mania, lethargy, stupor, or coma have occurred in patients administered muromonab-CD3. Patient with CNS disorders, cerebrovascular disease, neurological disturbances are at increased risk for neuro/psychiatric events.

References:

"Product Information. Orthoclone OKT 3 (muromonab-CD3)." Ortho Pharmaceutical Corporation, Raritan, NJ.
Sgro C "Side-effects of a monoclonal antibody, muromonab CD3 orthoclone OKT3: bibliographic review." Toxicology 105 (1995): 23-9
Capone PM, Cohen ME "Seizures and cerebritis associated with administration of OKT3." Pediatr Neurol 7 (1991): 299-301
Coleman AE, Norman DJ "OKT3 Encephalopathy." Ann Neurol 28 (1990): 837
Jeffrey RF, Johnson MH, Bamford JM, Giles GR, Brownjohn AM, Will EJ "Prolonged neurological disability following OKT3 therapy for acute renal transplant rejection." Transplantation 55 (1993): 677-9
Kehinde EO, Scriven SD, Feehally J, Veitch PS, Varty K, Bell PRF "Adverse effects of OKT3 therapy: increased risk with impaired renal function." Transplant Proc 26 (1994): 1945-7
Shihab FS, Barry JM, Norman DJ "Encephalopathy following the use of OKT3 in renal allograft transplantation." Transplant Proc 25 (1993): 31-4

Orthoclone OKT 3

Generic Name: muromonab-cd3

Brand Name:

Synonyms: Orthoclone OKT 3 (Intravenous), Orthoclone OKT3

What is Orthoclone OKT 3?