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Opdivo and Neurologic disorders

Result of checking the interaction of drug Opdivo and disease Neurologic disorders for safety when used together.

Check result:

Opdivo <> Neurologic disorders

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Nivolumab can cause immune-mediated encephalitis with no clear alternate etiology. It is recommended to evaluate patients with neurologic symptoms with consultation with a neurologist, brain MRI, lumbar puncture, and as clinically indicated. Withhold nivolumab in patients with new-onset moderate to severe neurologic signs or symptoms and evaluate to rule out infectious or other causes of moderate to severe neurologic deterioration. If other etiologies are ruled out, administer corticosteroids at a dose of 1 to 2 mg/kg/day prednisone equivalents for patients with immune-mediated encephalitis, followed by corticosteroid taper. Permanently discontinue nivolumab for immune-mediated encephalitis. If appropriate modify the dose according to manufacturer recommendations when nivolumab is administered in combination with ipilimumab, and if nivolumab is withheld, ipilimumab should also be withheld. Care should be taken when using nivolumab in patients with neurologic disorders.

Opdivo

Generic Name: nivolumab

Brand Name: Opdivo

Synonyms: n.a.

What is Opdivo?