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Opdivo and Colitis

Result of checking the interaction of drug Opdivo and disease Colitis for safety when used together.

Check result:

Opdivo <> Colitis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Immune-mediated colitis has been reported with the use of nivolumab. Monitor patients for signs and symptoms of colitis. It is recommended to administer corticosteroids at a dose of 1 to 2 mg/kg/day prednisone equivalents followed by corticosteroid taper for severe or life-threatening colitis. Administer corticosteroids at a dose of 0.5 to 1 mg/kg/day prednisone equivalents followed by corticosteroid taper for moderate colitis of more than 5 days duration; if worsening or no improvement occurs despite initiation of corticosteroids, increase dose to 1 to 2 mg/kg/day prednisone equivalents. If appropriate modify the dose according to manufacturer recommendations when nivolumab is administered in combination with ipilimumab, and if nivolumab is withheld, ipilimumab should also be withheld. Permanently discontinue nivolumab and ipilimumab for life-threatening or for recurrent colitis. Care should be taken when using nivolumab in patients with inflammatory bowel disease.

Opdivo

Generic Name: nivolumab

Brand Name: Opdivo

Synonyms: n.a.

What is Opdivo?