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Novaplus Irinotecan Hydrochloride and Hepatic dysfunction

Result of checking the interaction of drug Novaplus Irinotecan Hydrochloride and disease Hepatic dysfunction for safety when used together.

Check result:

Novaplus Irinotecan Hydrochloride <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Irinotecan clearance is diminished in patients with hepatic impairment. The magnitude of these effects is proportional to the degree of liver impairment as measured by elevations in total bilirubin and transaminase concentrations. However, the tolerability of irinotecan in patients with hepatic dysfunction (bilirubin greater than 2 mg/dl) has not been assessed sufficiently, and no recommendations for dosing are made by the manufacturers. Therapy with irinotecan should be administered cautiously to patients with or predisposed to compromised hepatic function. Clinical monitoring of hepatic function is recommended.

References:

"Product Information. Camptosar (irinotecan)." Pharmacia and Upjohn, Kalamazoo, MI.
Abigerges D, Chabot GG, Armand JP, Herait P, Gouyette A, Gandia D "Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients." J Clin Oncol 13 (1995): 210-21

Novaplus Irinotecan Hydrochloride

Generic Name: irinotecan

Brand Name: Camptosar

Synonyms: Irinotecan, Irinotecan (Conventional)

What is Novaplus Irinotecan Hydrochloride?