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Norpace CR and Hepatic dysfunction

Result of checking the interaction of drug Norpace CR and disease Hepatic dysfunction for safety when used together.

Check result:

Norpace CR <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Disopyramide is partially metabolized by the liver. The plasma half-life of disopyramide is prolonged in patients with hepatic dysfunction. Therapy with disopyramide should be administered cautiously and dosages reduced in patients with compromised hepatic function. Clinical monitoring of cardiac function (ECG) and hepatic function is recommended.

References:

Belpaire FM, Bogaert MG "Kinetics of disopyramide in decreased hepatic function ." Eur J Clin Pharmacol 32 (1987): 639
Tonkin AM, Joel SE, Reynolds JL "Unusual hepatocellular and cardiovascular complications of disopyramide." Chest 77 (1980): 125
"Product Information. Norpace (disopyramide)." Searle, Skokie, IL.
Doody PT "Disopyramide hepatotoxicity and disseminated intravascular coagulation." South Med J 75 (1982): 496-8
Antonelli D, Koltun B, Barzilay J "Acute hepatotoxic effect of disopyramide." Chest 86 (1984): 274
Bakris GL, Cross PD, Hammarsten JE "Disopyramide-associated liver dysfunction." Mayo Clin proc 58 (1983): 265-7

Norpace CR

Generic Name: disopyramide

Brand Name: Norpace, Norpace CR

Synonyms: n.a.

What is Norpace CR?