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Nolvadex and Hepatic dysfunction

Result of checking the interaction of drug Nolvadex and disease Hepatic dysfunction for safety when used together.

Check result:

Nolvadex <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Tamoxifen is extensively metabolized by the liver and excreted in the feces. Alteration in liver enzyme levels have been noted. Severe hepatic injuries such as fatty liver, cholestasis, hepatitis, and hepatic necrosis are rare, however, deaths have been reported. Patients should be instructed to immediately report any sign or symptoms of hepatic dysfunction such as jaundice, dark urine, right upper quadrant pain, or anorexia. Therapy with tamoxifen should be administered cautiously in patients with or predisposed to compromised hepatic function.

References:

Loomus GN, Aneja P, Bota RA "A case of peliosis hepatis in association with tamoxifen therapy." Am J Clin Pathol 80 (1983): 881-3
Blackburn AM, Amiel SA, Millis RR, Rubens RD "Tamoxifen and liver damage." Br Med J (Clin Res Ed) 289 (1984): 288
Agrawal BL, Zelkowitz L "Bone 'flare,' hypercalcemia, and jaundice after tamoxifen therapy ." Arch Intern Med 141 (1981): 1240
"Product Information. Nolvadex (tamoxifen)." Zeneca Pharmaceuticals, Wilmington, DE.
Ching CK, Smith PG, Long RG "Tamoxifen-associated hepatocellular damage and agranulocytosis ." Lancet 339 (1992): 940
Van Hoof M, Rahier J, Horsmans Y "Tamoxifen-induced steatohepatitis." Ann Intern Med 124 (1996): 855-6

Nolvadex

Generic Name: tamoxifen

Brand Name: Nolvadex, Soltamox

Synonyms: n.a.

What is Nolvadex?