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Nitrofurantoin Capsules and Hepatotoxicity

Result of checking the interaction of drug Nitrofurantoin Capsules and disease Hepatotoxicity for safety when used together.

Check result:

Nitrofurantoin Capsules <> Hepatotoxicity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of nitrofurantoin has rarely been associated with hepatotoxicity, including hepatitis, cholestatic jaundice, chronic active hepatitis, and hepatic necrosis. Nitrofurantoin macrocrystals capsules are contraindicated in patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with nitrofurantoin. Most acute reactions are self-limiting and resolve spontaneously, although fatalities have been reported. Therapy with nitrofurantoin should be administered cautiously in patients with liver disease. Periodic monitoring of liver function is recommended during prolonged therapy. The drug should be withdrawn immediately if hepatitis or liver damage occurs and is felt to be drug-related. Since nitrofurantoin is partially metabolized by the liver, a reduced dosage may also be necessary to prevent toxicity.

References:

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"Product Information. Macrodantin (nitrofurantoin)." Procter and Gamble Pharmaceuticals, Cincinnati, OH.
Sharp JR, Ishak KG, Zimmerman HJ "Chronic active hepatitis and sever heptic necrosis associated with nitrofurantoin." Ann Intern Med 92 (1980): 14-9
Hoener B, Patterson SE "Nitrofurantoin disposition." Clin Pharmacol Ther 29 (1981): 808-16
Thuluvath PJ, McKendrick MW "Nitrofurantoin induced chronic liver disease." J Antimicrob Chemother 18 (1986): 291-2
Mulberg AE, Bell LM "Fatal cholestatic hepatitis and multisystem failure associated with nitrofurantoin." J Pediatr Gastroenterol Nutr 17 (1993): 307-9
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"Product Information. Macrobid (nitrofurantoin)." Procter and Gamble Pharmaceuticals, Cincinnati, OH.
Miller AR, Addis BJ, Clarke PD "Nitrofurantoin and chronic active hepatitis." Ann Intern Med 97 (1982): 452
Maskell R "Nitrofurantoin induced chronic liver disease." J Antimicrob Chemother 19 (1987): 140
Black M, Rabin L, Schatz N "Nitrofurantoin-induced chronic active hepatitis." Ann Intern Med 92 (1980): 62-4
Burgert SJ, Burke JP, Box TD "Reversible nitrofurantoin-induced chronic active hepatitis and hepatic cirrhosis in a patient awaiting liver transplantation." Transplantation 59 (1995): 448-9
Stricker BH, Blok AP, Claas FH, Van Parys GE, Des Met VJ "Hepatic injury associated with the use of nitrofurans: a clinicopathological study of 52 reported cases." Hepatology 8 (1988): 599-608