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Antara and Cholelithiasis

Result of checking the interaction of drug Antara and disease Cholelithiasis for safety when used together.

Check result:

Antara <> Cholelithiasis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of fibric acid derivatives is contraindicated in patients with gallbladder disease. A significantly increased incidence of cholelithiasis has been observed in patients treated with the fibric acid derivative, clofibrate, presumably because of increased cholesterol excretion into the bile. Based on two separate studies (the WHO study and the Coronary Drug Project study), clofibrate use was associated with twice the risk of developing cholelithiasis and cholecystitis requiring surgery. Due to their structural and pharmacologic similarities, use of other fibric acid derivatives may be expected to carry the same risk.

References:

Roberts WC "Safety of fenofibrate--US and worldwide experience." Cardiology 76 (1989): 169-79
"Product Information. Tricor (fenofibrate)." Abbott Pharmaceutical, Abbott Park, IL.
Blane GF "Comparative toxicity and safety profile of fenofibrate and other fibric acid derivatives." Am J Med 83 (1987): 26-36
"Product Information. Atromid-S (clofibrate)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Lopid (gemfibrozil)." Parke-Davis, Morris Plains, NJ.

Antara

Generic Name: fenofibrate

Brand Name: Antara, Fenoglide, Lipofen, Tricor, Triglide, Lipidil Micro, Dom-Fenofibrate, Lipidil Supra, Lofibra, Lipidil EZ

Synonyms: n.a.

What is Antara?