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Nilutamide and Hepatic dysfunction

Result of checking the interaction of drug Nilutamide and disease Hepatic dysfunction for safety when used together.

Check result:

Nilutamide <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of nilutamide is contraindicated in patients with severe hepatic impairment. Patients with hepatic dysfunction may be at increased risk for nilutamide- associated hepatitis and marked increases in liver enzymes. Nilutamide is extensively metabolized by the liver and the metabolic activity and disposition of nilutamide may be altered in patients with severe hepatic impairment. Patients should be instructed to immediately report any sign or symptoms of hepatic dysfunction such as jaundice, dark urine, right upper quadrant pain, or anorexia. Clinical monitoring of hepatic function is recommended and nilutamide should be discontinued if liver transaminase levels increase two to three times the upper limit of normal.

References:

Gomez JL, Dupont A, Cusan L, Tremblay M, Tremblay M, Labrie F "Simultanwous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report." Am J Med 92 (1992): 563-6
Gomez JL, Dupont A, Cusan L, Tremblay M, Tremblay M, Labrie F "Simultaneous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report." Am J Med 92 (1992): 563-6
"Product Information. Nilandron (nilutamide)." Hoechst Marion-Roussel Inc, Kansas City, MO.

Nilutamide

Generic Name: nilutamide

Brand Name: Nilandron

Synonyms: n.a.

What is Nilutamide?