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Nifedical XL and Myocardial infarction

Result of checking the interaction of drug Nifedical XL and disease Myocardial infarction for safety when used together.

Check result:

Nifedical XL <> Myocardial infarction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Clinical trials studying the use of immediate-release nifedipine in patients who had just sustained myocardial infarctions have not demonstrated any benefit. In fact, in some trials, patients who received immediate-release nifedipine had significantly worse outcomes than patients who received placebo. The manufacturers state that immediate-release formulations of nifedipine should not be administered for 1 week after myocardial infarction. They should also be avoided in the setting of acute coronary syndrome, when infarction may be imminent.

References:

"Product Information. Adalat (nifedipine)." Bayer, West Haven, CT.
Abernathy DR, Schwrtz JB "Calcium-antagonist drugs." N Engl J Med 341 (1999): 1447-57
Furberg CD, Psaty BM, Meyer JV "Nifedipine: dose-related increase in mortality in patients with coronary heart disease." Circulation 92 (1995): 1326-31
Sleight P "Calcium antagonists during and after myocardial infarction." Drugs 51 (1996): 216-25
Kloner RA "Nifedipine in ischemic heart disease." Circulation 92 (1995): 1074-8
"Product Information. Procardia (nifedipine)." Pfizer US Pharmaceuticals, New York, NY.

Nifedical XL

Generic Name: nifedipine

Brand Name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat

Synonyms: Nifedical XL (Oral)

What is Nifedical XL?