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Antabuse and Psychoses

Result of checking the interaction of drug Antabuse and disease Psychoses for safety when used together.

Check result:

Antabuse <> Psychoses

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of disulfiram is contraindicated in patients with psychosis. Disulfiram may precipitate psychotic reactions and mood disorders, particularly when given in high dosages or with metronidazole or isoniazid. In some cases, however, the sudden withdrawal of alcohol alone can unmask underlying psychotic disorders.

References:

Fisher CM "'Catatonia' due to disulfiram toxicity." Arch Neurol 46 (1989): 798-804
Enghusen Poulsen H, Loft S, Andersen JR, Andersen M "Disulfiram therapy--adverse drug reactions and interactions." Acta Psychiatr Scand Suppl 369 (1992): 59-65;
Liddon SC, Satran R "Disulfiram (Antabuse) psychosis." Am J Psychiatry 123 (1967): 1284-9
Reisberg B "Catatonia associated with disulfiram therapy." J Nerv Ment Dis 166 (1978): 607-9
"Product Information. Antabuse (disulfiram)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Weddington WW, Jr Marks RC, Verghese JP "Disulfiram encephalopathy as a cause of the catatonia syndrome." Am J Psychiatry 137 (1980): 1217-9

Antabuse

Generic Name: disulfiram

Brand Name: Antabuse

Synonyms: n.a.

What is Antabuse?