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Nicardipine and Renal dysfunction

Result of checking the interaction of drug Nicardipine and disease Renal dysfunction for safety when used together.

Check result:

Nicardipine <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The systemic clearance of nicardipine has been shown to decrease in patients with renal impairment. Mean plasma concentrations were approximately two-fold higher than in healthy controls. Therapy with nicardipine should be administered cautiously in patients with impaired renal function.

References:

"Product Information. Cardene (nicardipine)." Syntex Laboratories Inc, Palo Alto, CA.
Ahmed JH, Grant AC, Rodger RSC, et al "Inhibitory effect of uraemia on the hepatic clearance and metabolism of nicardipine." Br J Clin Pharmacol 32 (1991): 57-62
Lee, SM, Williams R, Warnock D, et al "The effects of nicardipine in hypertensive subjects with impaired renal function." Br J Clin Pharmacol 22 (1986): s297-306

Nicardipine

Generic Name: nicardipine

Brand Name: Cardene IV, Cardene SR, Cardene

Synonyms: Nicardipine (oral/injection), NiCARdipine

What is Nicardipine?