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Nebupent and Hematologic toxicity

Result of checking the interaction of drug Nebupent and disease Hematologic toxicity for safety when used together.

Check result:

Nebupent <> Hematologic toxicity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hematologic toxicities have been associated occasionally with the parenteral use of pentamidine. Leukopenia and, less frequently, thrombocytopenia have been reported and may be severe (e.g., leukocyte count < 1000/mm3, platelet count < 20,000/mm3). Anemia, neutropenia, pancytopenia, and prolonged clotting time have occurred rarely. Therapy with pentamidine should be administered cautiously in patients with preexisting blood dyscrasias and/or bone marrow depression. Complete blood counts, including platelets, should be performed prior to and periodically during and after therapy. Marked depression of blood counts may be indication for withdrawal of pentamidine therapy.

References:

"Product Information. NebuPent (pentamidine)." Fujisawa, Deerfield, IL.
Andersen R, Boedicker M, Ma M, Goldstein EJ "Adverse reactions associated with pentamidine isethionate in AIDS patients: recommendations for monitoring therapy." Drug Intell Clin Pharm 20 (1986): 862-8
"Product Information. Pentam 300 (pentamidine)." Fujisawa, Deerfield, IL.

Nebupent

Generic Name: pentamidine

Brand Name: Nebupent, Pentam 300, Pentam

Synonyms: NebuPent

What is Nebupent?