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Nebivolol and valsartan and Hepatic impairment

Result of checking the interaction of drug Nebivolol and valsartan and disease Hepatic impairment for safety when used together.

Check result:

Nebivolol and valsartan <> Hepatic impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Metabolism of nebivolol is decreased in patients with moderate hepatic impairment. d-Nebivolol peak plasma concentration increased 3-fold, exposure (AUC) increased 10-fold, and the apparent clearance decreased by 86% in patients with moderate hepatic impairment (Child-Pugh Class B). Patients with liver disease may be at greater risk for adverse effects from nebivolol due to decreased drug clearance. Therapy with nebivolol should be administered cautiously in patients with liver disease. Dosage adjustments may be necessary. No formal studies have been performed in patients with severe hepatic impairment and nebivolol should be contraindicated for these patients.

Nebivolol and valsartan

Generic Name: nebivolol / valsartan

Brand Name: Byvalson

Synonyms: Nebivolol and Valsartan

What is Nebivolol and valsartan?