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Namzaric Titration Pack and Hepatic dysfunction

Result of checking the interaction of drug Namzaric Titration Pack and disease Hepatic dysfunction for safety when used together.

Check result:

Namzaric Titration Pack <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Donepezil is extensively metabolized by the liver (CYP450-2D6/3A4) to two active and various minor forms. The clearance of donepezil was decreased 20% in patients with stable alcoholic cirrhosis compared to healthy patients. Care should be exercised when using donepezil in patients with liver disease.

References:

"Product Information. Aricept (donepezil)." Pfizer US Pharmaceuticals, New York, NY.
Rogers SL, Friedhoff LT "The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US multicentre, randomized, double-blind, placebo-controlled trial." Dementia 7 (1996): 293-303

Namzaric Titration Pack

Generic Name: donepezil / memantine

Brand Name: Namzaric, Namzaric Titration Pack

Synonyms: Donepezil and memantine, Memantine and Donepezil

What is Namzaric Titration Pack?