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Naltrexone Hydrochloride And Bupropion Hydrochloride and Renal dysfunction

Result of checking the interaction of drug Naltrexone Hydrochloride And Bupropion Hydrochloride and disease Renal dysfunction for safety when used together.

Check result:

Naltrexone Hydrochloride And Bupropion Hydrochloride <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Bupropion metabolites, some of which are pharmacologically active with one-fifth to one-half the potency of the parent drug, are excreted by the kidney. Although pharmacokinetic studies have not been conducted in patients with renal impairment, it is conceivable that bupropion and its metabolites may accumulate in such patients to a greater extent than usual. Therefore, therapy with bupropion should be administered cautiously in the presence of significant renal impairment. A reduced dose and/or dosing frequency should be considered, and patients should be closely monitored for possible adverse effects that could indicate high drug or metabolite levels.

References:

"Product Information. Zyban (bupropion)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Wellbutrin (bupropion)." Glaxo Wellcome, Research Triangle Park, NC.

Naltrexone Hydrochloride And Bupropion Hydrochloride

Generic Name: bupropion / naltrexone

Brand Name: Contrave

Synonyms: Bupropion and naltrexone, Naltrexone and Bupropion

What is Naltrexone Hydrochloride And Bupropion Hydrochloride?