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Mycophenolate Mofetil Capsules and Hepatic dysfunction

Result of checking the interaction of drug Mycophenolate Mofetil Capsules and disease Hepatic dysfunction for safety when used together.

Check result:

Mycophenolate Mofetil Capsules <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Mycophenolate mofetil (inactive) undergoes complete presystemic metabolism to active MPA , further metabolism to inactive forms, some of which undergo enterohepatic circulation producing a second peak of MPA. Alcoholic cirrhosis (parenchymal cell damage) does not appear to affect the metabolism of MPA to inactive forms. Hepatic disease/dysfunction due to other etiologies may induce different effects.

References:

Kirklin JK, Bourge RC, Naftel DC, Morrow WR, Deierhoi MH, Kauffman RS, White-Williams C, Nomberg RI, Holman WL, Smith DC Jr "Treatment of recurrent heart rejection with mycophenolate mofetil (RS- 61443): initial clinical experience." J Heart Lung Transplant 13 (1994): 444-50
Sollinger HW, Deierhoi MH, Belzer FO, Diethelm AG, Kauffman RS "RS-61443--a phase I clinical trial and pilot rescue study." Transplantation 53 (1992): 428-32
"Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories, Nutley, NJ.
Bullingham RES, Nicholls A, Hale M "Pharmacokinetics of mycophenolate mofetil (RS61443): a short review." Transplant Proc 28 (1996): 925-9
Yatscoff RW, Keenan R, LeGatt DF "Single-dose pharmacokinetics of the new immunosuppressant RS-61443 in the rabbit." Ther Drug Monit 15 (1993): 400-4
Bullingham R, Monroe S, Nicholls A, Hale M "Pharmacokinetics and bioavailability of mycophenolate mofetil in healthy subjects after single-dose oral and intravenous administration." J Clin Pharmacol 36 (1996): 315-24
Hood KA, Zarembski DG "Mycophenolate mofetil: a unique immunosuppressive agent." Am J Health Syst Pharm 54 (1997): 285-94

Mycophenolate Mofetil Capsules

Generic Name: mycophenolate mofetil

Brand Name: Cellcept, Myfortic, MMF

Synonyms: Mycophenolate mofetil (oral/injection), Mycophenolate

What is Mycophenolate Mofetil Capsules?