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Myambutol and Renal dysfunction

Result of checking the interaction of drug Myambutol and disease Renal dysfunction for safety when used together.

Check result:

Myambutol <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Ethambutol is primarily eliminated by the kidney. Patients with renal impairment may be at greater risk for adverse effects from ethambutol, including optic neuritis, due to decreased drug clearance. Therapy with ethambutol should be administered cautiously in patients with renal impairment. Dosage adjustments are recommended in moderate renal impairment but should be based on serum levels of ethambutol.

References:

Varughese A, Brater DC, Benet LZ, Lee C-S "Ethambutol kinetics in patients with impaired renal function." Am Rev Respir Dis 134 (1986): 34-8
Collier J, Joekes AM, Philalithis PE, Thompson FD "Two cases of ethambutol nephrotoxicity." Br Med J 11/06/76 (1976): 1105-6
Stone WJ, Waldron JA, Dixon JH, et al "Acute diffuse interstitial nephritis related to chemotherapy of tuberculosis." Antimicrob Agents Chemother 10 (1976): 164-72
Garcia-Martin F, Mampaso F, de Arriba G, et al "Acute interstitial nephritis induced by ethambutol." Nephron 59 (1991): 679-80
De Feo P, Torlone E, Perriello G, Fanelli C, Epifano L, Di Vincenzo A, Modarelli F, Motolese M, Brunetti P, Bolli GB "Short-term metabolic effects of the ACE-inhibitor benazepril in type 2 diabetes mellitus associated with arterial hypertension." Diabete Metab 18 (1992): 283-8
"Product Information. Myambutol (ethambutol)." Lederle Laboratories, Wayne, NJ.
Insel J, Mirvis DM, Boland MJ, Cinquegrani MP, Shanes J, Rubin SA, Whalen JJ "A multicenter study of the safety and efficacy of benazepril hydrochloride, a long-acting angiotensin-converting enzyme inhibitor, in patients with chronic congestive heart failure." Clin Pharmacol Ther 45 (1989): 312-20

Myambutol

Generic Name: ethambutol

Brand Name: Myambutol

Synonyms: n.a.

What is Myambutol?