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Muromonab-cd3 Intravenous and Cardiovascular dysfunction

Result of checking the interaction of drug Muromonab-cd3 Intravenous and disease Cardiovascular dysfunction for safety when used together.

Check result:

Muromonab-cd3 Intravenous <> Cardiovascular dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of muromonab-CD3 is contraindicated in patients with uncompensated heart failure. Cardiovascular collapse, cardiac arrest, severe hypotension, shock, left ventricular dysfunction, and arrhythmias have occurred in patients administered muromonab-CD3. Patients with cardiovascular impairments are at increased risk for more serious cardiorespiratory complications (respiratory arrest, failure, distress, and/or cardiovascular collapse, cardiac arrest, angina, or myocardial infarction) from muromonab-CD3-associated Cytokine Release Syndrome.

References:

Spieker C, Zidek W, Barenbrock M, Wieneke R, Buchholz B, Rahn KH "Acute hypertension after renal allograft rejection therapy with OKT3 monoclonal antibody." J Int Med Res 19 (1991): 419-23
Hollenbeck M, Westhoff A, Bach D, Grabensee B, Kolvenbach R, Kniemeyer HW "Doppler sonography and renal graft vessel thromboses after OKT3 treatment." Lancet 340 (1992): 619-20
Costanzo-Nordin MR "Cardiopulmonary effects of OKT3: determinants of hypotension, pulmonary edema, and cardiac dysfunction." Transplant Proc 25 (1993): 21-4
Spieker C, Barenbrock M, Buchholz B, Heidenreich S, Zidek W "Cardiovascular effects of ATG and OKT3 in renal allograft recipients." Transplant Proc 24 (1992): 2594-5
Abramowicz D, Pradier O, Marchant A, Florquin S, De Pauw L, Vereerstraeten P, Kinnaert P, Vanherweghem JL, Goldman M "Induction of thromboses within renal grafts by high-dose prophylactic OKT3." Lancet 339 (1992): 777-8
Sgro C "Side-effects of a monoclonal antibody, muromonab CD3 orthoclone OKT3: bibliographic review." Toxicology 105 (1995): 23-9
Pradier O, Marchant A, Abramowicz D, De Pauw L, Vereerstraeten P, Kinnaert P, Vanherweghem JL, Capel P, Goldman M "Procoagulant effect of the OKT3 monoclonal antibody: involvement of tumor necrosis factor." Kidney Int 42 (1992): 1124-9
"Product Information. Orthoclone OKT 3 (muromonab-CD3)." Ortho Pharmaceutical Corporation, Raritan, NJ.

Muromonab-cd3 Intravenous

Generic Name: muromonab-cd3

Brand Name:

Synonyms: Muromonab-cd3 (Intravenous)

What is Muromonab-cd3 Intravenous?