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Mitotane and Adrenal insufficiency

Result of checking the interaction of drug Mitotane and disease Adrenal insufficiency for safety when used together.

Check result:

Mitotane <> Adrenal insufficiency

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Mitotane inhibits production of corticosteroids and alters extra-adrenal metabolism of endogenous and exogenous steroids. All patients treated with mitotane should be instructed to immediately report signs and symptoms of infection or other illnesses. Therapy with mitotane should be withheld immediately following shock or severe trauma or infection. Exogenous steroids should be administered since the suppressed adrenal may not immediately begin to secrete steroids.

References:

"Product Information. Lysodren (mitotane)." Bristol-Myers Squibb, Princeton, NJ.
Robinson BG, Hales IB, Henniker AJ, Ho K, Luttrell BM, Smee IR, Stiel JN "The effect of o,p'-DDD on adrenal steroid replacement therapy requirements." Clin Endocrinol (Oxf) 27 (1987): 437-44

Mitotane

Generic Name: mitotane

Brand Name: Lysodren

Synonyms: n.a.

What is Mitotane?