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Miltefosine and Renal dysfunction

Result of checking the interaction of drug Miltefosine and disease Renal dysfunction for safety when used together.

Check result:

Miltefosine <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Elevations in serum creatinine were observed in clinical trials of miltefosine for the treatment of cutaneous, mucosal, and visceral leishmaniasis. Therapy with miltefosine should be administered cautiously in patients with renal impairment, as the pharmacokinetics of miltefosine have not been studied in this population. Patients with serum creatinine or BUN levels 1.5 times or higher than the upper limit of normal were excluded from clinical trials. Renal function should be monitored weekly during therapy and for 4 weeks after completion of therapy. Miltefosine may commonly cause gastrointestinal adverse reactions. Patients should be advised to drink plenty of fluids to help prevent dehydration and kidney injury if they experience diarrhea or vomiting, and to seek medical attention if it is persistent or severe.

Miltefosine

Generic Name: miltefosine

Brand Name: Impavido

Synonyms: n.a.

What is Miltefosine?