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Milrinone Injection and Arrhythmias

Result of checking the interaction of drug Milrinone Injection and disease Arrhythmias for safety when used together.

Check result:

Milrinone Injection <> Arrhythmias

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of milrinone both intravenously and orally has been associated with increased frequency of ventricular arrhythmias, including nonsustained ventricular tachycardia. Long-term oral use has been associated with an increased risk of sudden death. Hence, patients receiving milrinone should be observed closely with the use of continuous electrocardiographic monitoring to allow the prompt detection and management of ventricular arrhythmias.

References:

Mancini D, LeJemtel T, Sonnenblick E "Intravenous use of amrinone for the treatment of the failing heart." Am J Cardiol 56 (1985): b8-15
Jelsema RD, Bhatia RK, Ganguly S "Use of intravenous amrinone in the short-term management of refractory heart failure in pregnancy." Obstet Gynecol 78 (1991): 935-6
Hasegawa R "Milrinone, a new agent for the treatment of congestive heart failure." Clin Pharm 5 (1986): 201-5
Silverman B, Merrill A, Gerber L "Clinical effects and side effects of amrinone. A study of 24 patients with chronic congestive heart failure." Arch Intern Med 145 (1985): 825-9
Ward A, Brogden RN, Heel RC, Speight TM, Avery GS "Amrinone: a preliminary review of its pharmacological properties and therapeutic use." Drugs 26 (1983): 468-502
Bottorff MB, Rutledge DR, Pieper JA "Evaluation of intravenous amrinone: the first of a new class of positive inotropic agents with vasodilator properties." Pharmacotherapy 5 (1985): 227-37
"Product Information. Primacor (milrinone)." Sanofi Winthrop Pharmaceuticals, New York, NY.
Packer M, Medina N, Yushak M "Hemodynamic and clinical limitations of long-term inotropic therapy with amrinone in patients with severe chronic heart failure." Circulation 70 (1984): 1038-47
DiBianco R, Shabetai R, Silverman BD, Leier CV, Benotti JR "Oral amrinone for the treatment of chronic congestive heart failure: results of a multicenter randomized double-blind and placebo- controlled withdrawal study." J Am Coll Cardiol 4 (1984): 855-66

Milrinone Injection

Generic Name: milrinone

Brand Name: Primacor, Primacor IV.

Synonyms: Milrinone

What is Milrinone Injection?