Mercaptopurine Tablets and TMPT enzyme deficiency
Result of checking the interaction of drug Mercaptopurine Tablets and disease TMPT enzyme deficiency for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Thioguanine is closely related structurally and functionally to mercaptopurine. A rare deficiency in the enzyme thiopurine methyltransferase (TMPT) results in an increased sensitivity to the myelosuppressive effects of both drugs causing rapid bone marrow suppression following initial mercaptopurine or thioguanine administration. Therapy with thioguanine or mercaptopurine should be administered cautiously and at a reduced dose in patients with TMPT deficiency.
- "Product Information. Tabloid (thioguanine)." Prasco Laboratories, Cincinnati, OH.
Generic Name: mercaptopurine
Brand Name: Purixan, Purinethol
Synonyms: Mercaptopurine
Mercaptopurine Tablets - Niedobór enzymu TMPT 
Mercaptopurine Tablets - Deficiência da enzima TMPT 
Mercaptopurine Tablets - Kekurangan enzim TMPT 
Mercaptopurine Tablets - Defisiensi enzim TMPT 
Mercaptopurine Tablets - Carenza di enzimi TMPT 
Mercaptopurine Tablets - Déficit enzymatique TMPT 
Mercaptopurine Tablets - TMPT-Enzymmangel 
Mercaptopurine Tablets - Deficiencia de la enzima TMPT 
Mercaptopurine Tablets - дефицит фермента ТМФТ 
Mercaptopurine Tablets - TMPT enzim eksikliği 
Mercaptopurine Tablets - نقص إنزيم TMPT 
Mercaptopurine Tablets - TMPT酶缺乏症