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Mektovi and Hepatic impairment

Result of checking the interaction of drug Mektovi and disease Hepatic impairment for safety when used together.

Check result:

Mektovi <> Hepatic impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Binimetinib concentrations may increase in patients with moderate or severe hepatic impairment. Reduce the dose of binimetinib for patients with moderate (total bilirubin > 1.5 and = 3 × ULN and any AST) or severe (total bilirubin levels > 3 × ULN and any AST) hepatic impairment. Dose adjustment is not recommended in patients with mild hepatic impairment (total bilirubin > 1 and = 1.5 × ULN and any AST or total bilirubin = ULN and AST > ULN).

Mektovi

Generic Name: binimetinib

Brand Name: Mektovi

Synonyms: n.a.

What is Mektovi?