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Marqibo and Neurologic dysfunction

Result of checking the interaction of drug Marqibo and disease Neurologic dysfunction for safety when used together.

Check result:

Marqibo <> Neurologic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of vincristine is contraindicated in patients with demyelinating conditions including Charcot-Marie-Tooth syndrome. Neurotoxicity associated with vincristine therapy is dose-related and frequently sequential. Sensorimotor (paresthesia, decreased deep- tendon reflex, ataxia, paralysis), autonomic (constipation and adynamic ileus), and CNS (mental status changes, seizures, coma) neurotoxicity have been reported. Patients with existing neuromuscular or neurologic diseases may be at increased risk for toxicity with vincristine therapy. Therapy with vincristine should be administered cautiously and dosage reduction considered in patients with neurologic dysfunction.

References:

Postma TJ, Benard BA, Huijgens PC, Ossenkoppele GJ, Heimans JJ "Long-term effects of vincristine on the peripheral nervous system." J Neurooncol 15 (1993): 23-7
Johnson FL, Bernstein ID, Hartmann JR, Chard RL Jr "Seizures associated with vincristine sulfate therapy." J Pediatr 82 (1973): 699-702
Weiden PL, Wright SE "Vincristine neurotoxicity." N Engl J Med 286 (1972): 1369-70
Watkins SM, Griffin JP "High incidence of vincristine-induced neuropathy in lymphomas." Br Med J 1 (1978): 610-2
"Product Information. Oncovin (vincristine)." Lilly, Eli and Company, Indianapolis, IN.
Warrier RP, Tan T, Patel Y, Yu LC, Quarls K, Shenoy S "Vincristine neurotoxicity." Indian Pediatr 29 (1992): 370-3
Delaney P "Vincristine-induced laryngeal nerve paralysis." Neurology 32 (1982): 1285-8
Martin J, Mainwaring D "Letter: Coma and convulsions associated with vincristine therapy." Br Med J 4 (1973): 782-3
Annino DJ Jr, MacArthur CJ, Friedman EM "Vincristine-induced recurrent laryngeal nerve paralysis." Laryngoscope 102 (1992): 1260-2
Jalihal S, Roebuck N "Acute vincristine neurotoxicity." Lancet 1 (1985): 637
Rosenthal S, Kaufman S "Vincristine neurotoxicity." Ann Intern Med 80 (1974): 733-7
Tormey DC "Neurotoxicity of vincristine." Lancet 1 (1973): 1312