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Lysodren and Neurologic disorder

Result of checking the interaction of drug Lysodren and disease Neurologic disorder for safety when used together.

Check result:

Lysodren <> Neurologic disorder

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Unspecified brain damage and impairment of function have been reported during prolonged mitotane therapy. Therapy with mitotane should be administered cautiously to patients with neurologic impairment. Clinical monitoring of behavior and neurological function is recommended when continuous mitotane therapy exceeds two years.

References:

Hogan TF, Citrin DL, Johnson BM, Nakamura S, Davis TE, Borden EC "o,p'-DDD (mitotane) therapy of adrenal cortical carcinoma: observations on drug dosage, toxicity, and steroid replacement." Cancer 42 (1978): 2177-81
Lanser JB, van Seters AP, Moolenaar AJ, Haak HR, Bollen EL "Neuropsychologic and neurologic side effects of mitotane and reversibility of symptoms." J Clin Oncol 10 (1992): 1504
"Product Information. Lysodren (mitotane)." Bristol-Myers Squibb, Princeton, NJ.

Lysodren

Generic Name: mitotane

Brand Name: Lysodren

Synonyms: n.a.

What is Lysodren?