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Lopressor HCT and Liver disease

Result of checking the interaction of drug Lopressor HCT and disease Liver disease for safety when used together.

Check result:

Lopressor HCT <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Metoprolol is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from metoprolol due to decreased drug clearance. Therapy with metoprolol should be administered cautiously in patients with liver disease. Dosage adjustments may be necessary.

References:

Silas JH, McGourty JC, Lennard MS, Tucker GT, Woods HF "Polymorphic metabolism of metoprolol: clinical studies." Eur J Clin Pharmacol 28 (1985): 85-8
Regardh C-G, Jordo L, Ervik M, et al "Pharmacokinetics of metoprolol in patients with hepatic cirrhosis." Clin Pharmacokinet 6 (1981): 375-88
Johnson JA, Burlew BS "Metoprolol metabolism via cytochrome p4502d6 in ethnic populations." Drug Metab Dispos 24 (1996): 350-5
Regardh CG, Borg KO, Johansson R, et al "Pharmacokinetic studies on the selective beta1-receptor antagonist metoprolol in man." J Pharmacokinet Biopharm 2 (1974): 347-64

Lopressor HCT

Generic Name: hydrochlorothiazide / metoprolol

Brand Name: Lopressor HCT, Dutoprol

Synonyms: n.a.

What is Lopressor HCT?

Another drug Delete

Lopressor HCT <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

Consumer:

Patients with severe liver disease or cirrhosis are very susceptible to thiazide-induced hypokalemic hypochloremic alkalosis. Blood ammonia concentrations may be further increased in patients with previously elevated concentrations. Hepatic encephalopathy and death have occurred secondary to the electrolyte alterations accompanying diuretic use. Therapy with thiazide diuretics should be administered cautiously in patients with impaired hepatic function or progressive liver disease, and discontinued promptly if signs of impending hepatic coma appear (e.g., tremors, confusion, and increased jaundice).

References:

Sherlock S, Senewiratne B, Scott A, Walker JG "Complications of diuretic therapy in hepatic cirrhosis." Lancet 1 (1966): 1049-52
"Product Information. Zaroxolyn (metolazone)." Rhone-Poulenc Rorer, Collegeville, PA.
"Product Information. Metahydrin (trichlormethiazide)." Hoechst Marion-Roussel Inc, Kansas City, MO.
"Product Information. Diucardin (hydroflumethiazide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Enduron (methyclothiazide)." Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Renese-R (reserpine-polythiazide)." Pfizer US Pharmaceuticals, New York, NY.
"Product Information. Thalitone (chlorthalidone)." Monarch Pharmaceuticals Inc, Bristol, TN.
"Product Information. HydroDIURIL (hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
Sherlock S, Walker JG, Senewiratne B, Scott A "The complications of diuretic therapy in patients with cirrhosis." Ann N Y Acad Sci 139 (1966): 497-505
"Product Information. Lozol (indapamide)." Rhone-Poulenc Rorer, Collegeville, PA.
Aneckstein AG, Weingold AB "Chlorothiazide-induced hepatic coma in pregnancy." Am J Obstet Gynecol 95 (1966): 136-7
"Product Information. Diuril (chlorothiazide)." Merck & Co, Inc, West Point, PA.