- Generic Name: amitriptyline
- Dosage Forms: n.a.
- Other Brand Names: Vanatrip, Elavil, Endep
What is Amitriptyline Hydrochloride?
Management of major depressive disorder.
Anxiety and Depressive Disorders
Has been used in fixed combination with chlordiazepoxide in the management of depression associated with moderate to severe anxiety.
Management of moderate to severe anxiety and/or agitation (in fixed combination with perphenazine) in patients with depressed mood.
Management of severe anxiety and/or agitation (in fixed combination with perphenazine) in patients with depression.
Management of depression and anxiety (in fixed combination with perphenazine) in association with chronic physical disease.
Psychotic Disorders
Management of acute depressive episodes (in fixed combination with perphenazine) in patients with schizophrenia.
Attention Deficit Hyperactivity Disorder
Second-line agent in attention deficit hyperactivity disorder (ADHD) patients unable to tolerate or unresponsive to stimulants; should be used only under close supervision.
Associated with a narrower margin of safety than some other therapeutic agents; use only if clearly indicated and with careful monitoring, including baseline and subsequent determinations of ECG and other parameters.
Migraine
Medium to high efficacy for prophylaxis of migraine headache.
Eating Disorders
Equivocal efficacy for management of eating disorders (e.g., bulimia, anorexia nervosa); avoid use in underweight individuals and in those exhibiting suicidal ideation.
Bipolar Disorder
Has been used for the short-term management of acute depressive episodes in bipolar disorder.
TCAs associated with a greater risk of precipitating hypomania or manic episodes than other classes of antidepressants; should always be used in combination with a mood stabilizer (e.g., lithium).
Postherpetic Neuralgia
Among the drugs of choice for the symptomatic treatment of postherpetic neuralgia.
Insomnia
Less effective for insomnia and associated with more serious adverse reactions than conventional hypnotics.