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Lincomycin Hydrochloride and Renal/liver disease

Generic Name: lincomycin
Dosage Forms: n.a.
Other Brand Names: Lincocin , Lincorex, L-Mycin, Bactramycin

Result of checking the interaction of drug Lincomycin Hydrochloride and disease Renal/liver disease for safety when used together.

Check result:

Lincomycin Hydrochloride <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Lincomycin is partially metabolized by the liver and eliminated in the urine, bile and feces as both parent drug and metabolites. The serum concentration of lincomycin may be increased and the half-life prolonged in patients with renal and/or liver disease. Therapy with lincomycin should be administered cautiously in patients with significantly impaired renal and/or hepatic function. In patients with severe renal impairment (CrCl < 10 mL/min), the manufacturer recommends using 25% to 30% of the normal dosage. Due to inadequate data in patients with liver disease, the manufacturer does not recommend its use except under special clinical circumstances. Periodic renal and liver function tests should be performed during prolonged therapy.

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