Levonorgestrel (Systemic) and Thromboembolism
Result of checking the interaction of drug Levonorgestrel (Systemic) and disease Thromboembolism for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:The use of levonorgestrel is considered by manufacturers to be contraindicated in patients with active thrombophlebitis or thromboembolic disorders. Some manufacturers also recommend not using progestogens in patients with a history of thromboembolic or cerebrovascular disease. While the role of progestogens in the development of thromboembolic events associated with hormonal therapy is often unclear and thought to be secondary to that of estrogens, it may not be insignificant. Levonorgestrel implants, specifically, have been associated with thrombophlebitis and superficial phlebitis, which were more common in the arm of insertion and sometimes related to trauma to the arm. There have also been post-marketing reports of stroke and myocardial infarction coincident with the use of levonorgestrel implants.
- "Product Information. Norplant System (levonorgestrel)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Provera (medroxyprogesterone)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Triphasil (ethinyl estradiol-levonorgestrel)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Depo-Provera (medroxyprogesterone)." Pharmacia and Upjohn, Kalamazoo, MI.
Generic Name: levonorgestrel
Brand Name: EContra EZ, Fallback Solo, My Way, Next Choice, Opcicon One-Step, Plan B One-Step, React, Aftera, EContra One-Step, My Choice, My Way, New Day, Next Choice One Dose, Take Action, Kyleena, Liletta, Mirena, Skyla
Synonyms: Levonorgestrel emergency contraceptive, Levonorgestrel (IUD)