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Leucovorin Tablets and Seizures

Generic Name: leucovorin
Dosage Forms: n.a.
Other Brand Names: Wellcovorin

Result of checking the interaction of drug Leucovorin Tablets and disease Seizures for safety when used together.

Check result:

Leucovorin Tablets <> Seizures

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Seizures have occurred rarely during administration of leucovorin, primarily in patients receiving high dose leucovorin or leucovorin in combination with 5-fluorouracil, or in patients with a history of seizures or central nervous system abnormalities (unspecified). Folic acid in large amounts may counter the anticonvulsant effects of phenobarbital, phenytoin, and pimozide. Clinical monitoring of seizure activity is recommended and modification of anticonvulsant therapy may be necessary.

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