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Letrozole and ribociclib and Liver disease

Result of checking the interaction of drug Letrozole and ribociclib and disease Liver disease for safety when used together.

Check result:
Letrozole and ribociclib <> Liver disease
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Letrozole is extensively metabolized by the liver. The pharmacokinetic disposition of letrozole has not been assessed in patients with severe hepatic impairment. No dosage modification is recommended for patients with mild to moderate hepatic impairment, however, therapy with letrozole should be administered cautiously to patients with severe hepatic impairment.

References:
  • "Product Information. Femara (letrozole)." Novartis Pharmaceuticals, East Hanover, NJ.
Letrozole and ribociclib

Generic Name: letrozole / ribociclib

Brand Name: Kisqali Femara Co-Pack 200 mg-25 mg Dose, Kisqali Femara Co-Pack 400 mg-25 mg Dose, Kisqali Femara Co-Pack 600 mg-25 mg Dose

Synonyms: n.a.

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