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Lamprene and GI effects

Result of checking the interaction of drug Lamprene and disease GI effects for safety when used together.

Check result:

Lamprene <> GI effects

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of clofazimine has been associated with severe abdominal symptoms including splenic infarction, bowel obstruction, and GI bleeding. Death has been reported following severe abdominal symptoms. Crystalline deposits have been found in the intestinal mucosa, liver, gallbladder, bile, spleen, adrenals, subcutaneous fat, mesenteric lymph nodes, muscles, bone and skin. Clofazimine should be administered cautiously in patients with GI problems such as abdominal pain and diarrhea.

References:

Ravi S, Holubka J, Veneri R, Youn K, Khatib R "Clofazimine-induced eosinophilic gastroenteritis in AIDS." Am J Gastroenterol 88 (1993): 612-3
Holdiness MR "Clinical pharmacokinetics of clofazimine: a review." Clin Pharmacokinet 16 (1989): 74-85
"Product Information. Lamprene (clofazimine)." Novartis Pharmaceuticals, East Hanover, NJ.
Venencie PY, Cortez A, Orieux G, Jost JL, Chomette G, Puissant A "Clofazimine enteropathy." J Am Acad Dermatol 15 (1986): 290-1
Merrett MN, King RW, Farrell KE, Zeimer H, Guli E "Orange/black discolouration of the bowel (at laparotomy) due to clofazimine." Aust N Z J Surg 60 (1990): 638-9
Belaube P, Devaux J, Pizzi M, Boutboul R, Privat Y "Small bowel deposition of crystals associated with the use of clofazimine (Lamprene) in the treatment of prurigo nodularis." Int J Lepr Other Mycobact Dis 51 (1983): 328-30
Chong PY, Ti TK "Severe abdominal pain in low dosage clofazimine." Pathology 25 (1993): 24-6

Lamprene

Generic Name: clofazimine

Brand Name:

Synonyms: Lamprene (Oral)

What is Lamprene?