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Amantadine Oral Solution USP and Psychoses/depression

Result of checking the interaction of drug Amantadine Oral Solution USP and disease Psychoses/depression for safety when used together.

Check result:

Amantadine Oral Solution USP <> Psychoses/depression

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Amantadine may precipitate or exacerbate psychotic symptoms. Rarely, suicide attempts and suicidal ideation have also been reported, some of which occurred in patients with no prior history of psychiatric illness who were taking short courses of amantadine for influenza. Therapy with amantadine should be administered cautiously in patients with a history of psychiatric disorders, emotional instability, or substance abuse, and particularly if they are elderly. It may be prudent to refrain from dispensing large quantities of amantadine to these patients to prevent intentional overdose, which is potentially fatal.

References:

Millet VM, Dreisbach M, Bryson YJ "Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine." Antimicrob Agents Chemother 21 (1982): 1-4
Hayden FG, Hoffman HE, Spyker DA "Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics." Antimicrob Agents Chemother 23 (1983): 458-64
Millet VM, Dreisbach M, Bryson YJ "Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine." Antimicrob Agents Chemother 21 (1982): 1-4
Armbruster KF, Rahn AC, Ing TS, Halper IS, Oyama JH, Klawans HL "Amantadine toxicity in a patient with renal insufficiency." Nephron 13 (1974): 183-6
Borison RL "Amantadine-induced psychosis in a geriatric patient with renal disease." Am J Psychiatry 136 (1979): 111-2
Noveske FG "Breakthrough panic after amantadine treatment in a parkinson's disease patient." J Clin Psychiatry 57 (1996): 374
Degelau J, Somani S, Cooper SL, Irvine PW "Occurrence of adverse effects and high amantadine concentrations with influenza prophylaxis in the nursing home." J Am Geriatr Soc 38 (1990): 428-32
Stroe AE, Hall J, Amin F "Psychotic episode related to phenylpropanolamine and amantadine in a healthy female." Gen Hosp Psychiatry 17 (1995): 457-8
Strange KC, Little DW, Blatnik B "Adverse reactions to amantadine prophylaxis of influenza in a retirement home." J Am Geriatr Soc 33 (1991): 700-5
Postma JU, van Tilburg W "Visual hallucinations and delirium during treatment with amantadine (Symmetrel)." J Am Geriatr Soc 23 (1975): 212-5
Nestelbaum Z, Siris SG, Rifkin A, Klar H, Reardon GT "Exacerbation of schizophrenia associated with amantadine." Am J Psychiatry 143 (1986): 1170-1
Rizzo M, Biandrate P, Tognoni, Morselli PL "Amantadine in depression: relationship between behavioural effects and plasma levels." Eur J Clin Pharmacol 5 (1973): 226-8
Somani SK, Degelau J, Cooper SL, Guay DR, Ehresman D, Zaske D "Comparison of pharmacokinetic and safety profiles of amantadine 50- and 100-mg daily doses in elderly nursing home residents." Pharmacotherapy 11 (1991): 460-6
Ing TS, Daugirdas JT, Soung LS, et al "Toxic effects of amantadine in patients with renal failure." Can Med Assoc J 120 (1979): 695-8
"Product Information. Symmetrel (amantadine)." DuPont Pharmaceuticals, Wilmington, DE.