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Indinavir Sulfate and Liver disease

Result of checking the interaction of drug Indinavir Sulfate and disease Liver disease for safety when used together.

Check result:

Indinavir Sulfate <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Indinavir is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from indinavir due to decreased drug clearance. Therapy with indinavir should be administered cautiously in patients with liver disease. A dosage reduction to 600 mg three times a day is recommended for patients with mild to moderate hepatic insufficiency due to cirrhosis.

References:

Sommadossi JP "HIV protease inhibitors: pharmacologic and metabolic distinctions." AIDS 13 (1999): s29-40
Chiba M, Hensleigh M, Nishime JA, Balani SK, Lin JH "Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor." Drug Metab Dispos 24 (1996): 307-14
Balani SK, Woolf EJ, Hoagland VL, Sturgill MG, Deutsch PJ, Yeh KC, Lin JH "Disposition of indinavir, a potent HIV-1 protease inhibitor, after an oral dose in humans." Drug Metab Dispos 24 (1996): 1389-94
"Product Information. Crixivan (indinavir)." Merck & Co, Inc, West Point, PA.

Indinavir Sulfate

Generic Name: indinavir

Brand Name: Crixivan

Synonyms: Indinavir

What is Indinavir Sulfate?