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Imuran and Liver disease

Result of checking the interaction of drug Imuran and disease Liver disease for safety when used together.

Check result:
Imuran <> Liver disease
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Azathioprine is metabolically converted to the pharmacologically active 6-mercaptopurine (6-MP). Conversion to 6-MP and metabolism of 6-MP may be impaired in patients with liver disease. Therapy with azathioprine should be administered cautiously in patients with liver disease. Monitoring liver function is recommended in these patients.

References:
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  • Read AE, Wiesner RH, LaBrecque DR, et al "Hepatic veno-occlusive disease associated with renal transplantation and azathioprine therapy." Ann Intern Med 104 (1986): 651-5
  • Hohlfeld R, Michels M, Heininger K, Besinger U, Toyka KV "Azathioprine toxicity during long-term immunosuppression of generalized myasthenia gravis." Neurology 38 (1988): 258-61
  • Cooper C, Minihane N, Cotton DW, Cawley MI "Azathioprine hypersensitivity manifesting as acute focal hepatocellular necrosis." J R Soc Med 79 (1986): 171-3
  • DePinho RA, Goldberg CS, Lefkowitch JH "Azathioprine and the liver: evidence favoring idiosyncratic, mixed cholestatic-hepatocellular injury in humans." Gastroenterology 86 (1984): 162-5
  • Singh G, Fries JF, Spitz P, Williams CA "Toxic effects of azathioprine in rheumatoid arthritis: a national post-marketing perspective." Arthritis Rheum 32 (1989): 837-43
  • Small P, Lichter M "Probably azathioprine hepatotoxicity: a case report." Ann Allergy 62 (1989): 518-20
  • Gerlag PG, van Hooff JP "Hepatic sinusoidal dilatation with portal hypertension during azathioprine treatment: a cause of chronic liver disease after kidney transplantation." Transplant Proc 19 (1987): 3699-703
  • Millard PR, Herbertson BM, Evans DB, Calne RY "Azathioprine hepatotoxicity in renal transplantation." Transplantation 16 (1973): 527-30
  • Meys E, Devogelaer JP, Geubel A, Rahier J, de Deuxchaisnes CN "Fever, hepatitis and acute interstitial nephritis in a patient with rheumatoid arthritis. Concurrent manifestations of azathioprine hypersensitivity." J Rheumatol 19 (1992): 807-9
  • Liano F, Moreno A, Matesanz R, et al "Veno-occlusive hepatic disease of the liver in renal transplantation: is azathioprine the cause?" Nephron 51 (1989): 509-16
  • Jeurissen ME, Boerbooms AM, van de Putte LB, Kruijsen MW "Azathioprine induced fever, chills, rash, and hepatotoxicity in rheumatoid arthritis." Ann Rheum Dis 49 (1990): 25-7
  • Katska DA, Saul SH, Jorkasky D, Sigal H, Reynolds JC, Soloway RD "Azathioprine and hepatic venocclusive disease in renal transplant patients." Gastroenterology 90 (1986): 446-54
  • Duvoux C, Kracht M, Lang P, Vernant JP, Zafrani ES, Dhumeaux D "Hyperplasie nodulaire regenerative du foie associee a la prise d'azathioprine." Gastroenterol Clin Biol 15 (1991): 968-73
  • Sterneck M, Wiesner R, Ascher N, et al "Azathioprine hepatotoxicity after liver transplantation." Hepatology 14 (1991): 806-10
  • Lemley DE, Delacy LM, Seeff LB, Ishak KG, Nashel DJ "Azathioprine induced hepatic veno-occlusive disease in rheumatoid arthritis." Ann Rheum Dis 48 (1989): 342-6
Imuran

Generic Name: azathioprine

Brand Name: Azasan, Imuran

Synonyms: n.a.

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